Miscellaneous TopicsImplications of altered NAD metabolism

Fred
Posts: 274
Joined: Tue Aug 13, 2019 3:17 pm
Location: Stockholm, Sweden

Implications of altered NAD metabolism

Post by Fred » Tue Dec 03, 2019 3:26 am

"Numerous studies have shown that NAD levels decrease with aging and under disturbed nutrient conditions, such as obesity. Additionally, a decline in NAD levels is closely related to the development of various metabolic disorders, including diabetes and fatty liver disease.

In addition, many studies have revealed that administration of NAD precursors, such as nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), efficiently increase NAD levels in various tissues and prevent such metabolic diseases.

These NAD precursors are contained in natural foods, such as cow milk, vegetables, and meats. Therefore, altered NAD metabolism can be a practical target for nutritional intervention.

Recently, several human clinical trials using NAD precursors have been conducted to investigate the safety, pharmacokinetics, and efficacy against metabolic disorders such as glucose intolerance.

In this review, we summarize current knowledge on the implications of NAD metabolism in metabolic diseases and discuss the outcomes of recent human clinical trials.

https://jbiomedsci.biomedcentral.com/ar ... 019-0527-8


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Fred
Registered dietitian, Sweden.
Drdavid
Posts: 371
Joined: Thu Aug 15, 2019 9:59 am

Re: Implications of altered NAD metabolism

Post by Drdavid » Wed Dec 04, 2019 12:24 pm

Thanks Fred another great piece of literature that further documents NAD/NMN/NR health benefits.
Fred
Posts: 274
Joined: Tue Aug 13, 2019 3:17 pm
Location: Stockholm, Sweden

Re: Implications of altered NAD metabolism

Post by Fred » Wed Dec 04, 2019 12:40 pm

Drdavid wrote:
Wed Dec 04, 2019 12:24 pm
Thanks Fred another great piece of literature that further documents NAD/NMN/NR health benefits.
Hopefully, the promising health benefits will be applicable to humans too. We´re all awaiting both further pharmacokinetic data and proof of efficacy against disease, or at least biomarkers of disease, in a clinical trial. Let´s hope we´ll see that in 2020.
Fred
Registered dietitian, Sweden.
Fred
Posts: 274
Joined: Tue Aug 13, 2019 3:17 pm
Location: Stockholm, Sweden

Re: Implications of altered NAD metabolism

Post by Fred » Wed Dec 04, 2019 3:56 pm

Fred wrote:
Wed Dec 04, 2019 12:40 pm
Drdavid wrote:
Wed Dec 04, 2019 12:24 pm
Thanks Fred another great piece of literature that further documents NAD/NMN/NR health benefits.
Hopefully, the promising health benefits described in the literature will be applicable to humans too.

We´re all awaiting both further pharmacokinetic data and proof of efficacy against disease, or at least biomarkers of disease, in a clinical trial. Let´s hope we´ll see that in 2020.
Fred
Registered dietitian, Sweden.
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