Healthy Aging News and ResearchVirus infection and aging

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AlbertY
Posts: 112
Joined: Mon Aug 12, 2019 4:01 pm
Location: Boston, MA

Virus infection and aging

Post by AlbertY » Mon Mar 16, 2020 2:28 pm

Hi all, recently there is not much interesting news about aging research and labs in Harvard med school will be closed for the next few months. Hope everyone stays safe!

Recently I'm working on a project about the COVID19, data is unpublished so I can't talk too much here but we found that the ACE2, the receptor that virus used to get into the cell, is strongly (oddly) associate with lifespan. And old people actually have more ACE2 in the liver and kidney. Also, based on data from Sinclair lab, virus infection alone (even though the virus they are using actually doing no malignant things but just expressing the fluorescent protein GFP), can increase the biological age of the cell (here it is not significant, but I bet it will be with larger sample size).

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So altogether, this virus is very dangerous to old people. Not very deadly to young people but MIGHT still accelerate the aging process in young people after getting it. Take care!


Ph.D. student at Harvard Medical School, doing research on aging
drkris69
Posts: 406
Joined: Tue Aug 20, 2019 2:41 pm

Re: Virus infection and aging

Post by drkris69 » Tue Mar 17, 2020 8:56 am

Thanks AlbertY for posting this, very interesting indeed.
NewLifeScience
Posts: 180
Joined: Thu Aug 22, 2019 4:17 pm

Re: Virus infection and aging

Post by NewLifeScience » Tue Mar 17, 2020 3:05 pm

Yes I have an 84 year old mom i am watching closely.

She gets NMN and The NAD+ Booster. I think it can help her immune system. But if she gets infected, I will stop all the suppliments.

We are in a relatively remote part of Canada with no local cases yet. But we have to stay vigilant.
Taking:
Resveratrol 400mg since June 2019; 600mg since October 1
NMN Sublingual 250mg since june 2019 500mg since September 2019; 600mg since Dec 1, 2019
NAD+ Nasal, appx 100mg per day since September 2019; 200mg per day beginning mid November
OzSport
Posts: 193
Joined: Wed Aug 21, 2019 5:08 am

Re: Virus infection and aging

Post by OzSport » Sat Mar 21, 2020 11:05 pm

Thanks for sharing, AlbertY! Looking forward to reading the research when it's officially published. :D
CeeJayBee
Posts: 85
Joined: Thu Aug 22, 2019 4:19 pm

Re: Virus infection and aging

Post by CeeJayBee » Mon Mar 23, 2020 8:02 pm

AlbertY wrote:
Mon Mar 16, 2020 2:28 pm
Hi all, recently there is not much interesting news about aging research and labs in Harvard med school will be closed for the next few months. Hope everyone stays safe!

Recently I'm working on a project about the COVID19, data is unpublished so I can't talk too much here but we found that the ACE2, the receptor that virus used to get into the cell, is strongly (oddly) associate with lifespan. And old people actually have more ACE2 in the liver and kidney. Also, based on data from Sinclair lab, virus infection alone (even though the virus they are using actually doing no malignant things but just expressing the fluorescent protein GFP), can increase the biological age of the cell (here it is not significant, but I bet it will be with larger sample size).

Image

So altogether, this virus is very dangerous to old people. Not very deadly to young people but MIGHT still accelerate the aging process in young people after getting it. Take care!
Hi Albert
Is any of the work you are doing related to developing of a vaccine?
jessicaP
Posts: 15
Joined: Sun Nov 03, 2019 10:52 am

Re: Virus infection and aging

Post by jessicaP » Tue Mar 24, 2020 9:31 pm

It is frustrating, but anyone who would be working on a vaccine says 10 to 12 months at best. That is a long time, but maybe if social distancing slows in down to a crawl, a residue of our normal life may partially resume.
Drdavid
Posts: 587
Joined: Thu Aug 15, 2019 9:59 am

Re: Virus infection and aging

Post by Drdavid » Thu Mar 26, 2020 7:13 am

Thank you for the update. Can this receptor be modified or bound? Does NAD+/NMN interact with this receptor?
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