NMNNMN Dosage

smokinjoe
Posts: 74
Joined: Sun Sep 01, 2019 9:24 am

Re: NMN Dosage

Post by smokinjoe » Sun Jun 07, 2020 8:41 pm

jocko6889 wrote:
Thu Jun 04, 2020 12:16 pm
RobSmith wrote:
Thu Jun 04, 2020 11:13 am
jocko6889 wrote:
Thu Jun 04, 2020 3:43 am
It is recommended you take something to replace lost methyl groups at the dose we're talking about. I was using 750mg of TMG (trimethylglycine) per day until I read that Sinclair recently switched from that to a combination of Methyl Folate and Methyl B12. Maybe this is a healthier alternative, so I've done the same. Didn't know his dosage of each so I'm guessing on that until I get more info.
Hey, this is the first time I've seen anyone comment "lost methyl groups". Could someone explain what this means, please?
Byproducts from NAD+ use are excreted out the urine along with a methyl group. Depending on how much NMN you are using, this could cause a shortage of methyl groups, in which case you should supplement. Methyl groups are needed for synthesizing creatine for muscle and dopamine for the brain. Having a shortage could mean feeling tired and/or depressed.
Can this happen with SL NMN? Or just NAD+?


Male, 41
no i don't smoke :)

taking:
NAD+ nasal since August 15, 2019
NMN powder, 125 mg per day; 625 per day since Oct 1, 2019
Resveratrol 600mg, since September 15, 2019
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jocko6889
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Location: Tulsa, OK
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Re: NMN Dosage

Post by jocko6889 » Sun Jun 07, 2020 9:33 pm

Arnie wrote:
Sun Jun 07, 2020 7:31 pm
jocko6889 wrote:
Sun Jun 07, 2020 1:15 pm
zmm wrote:
Sun Jun 07, 2020 10:24 am


Is there somewhere I can hear or read the Glenda interview?
It's not posted anywhere to my knowledge yet.
How did you find out about it?
The interview was posted briefly on a Facebook group page but taken down for unknown reasons. Waiting the see whether it will reappear on YouTube somewhere.
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jocko6889
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Re: NMN Dosage

Post by jocko6889 » Sun Jun 07, 2020 9:35 pm

smokinjoe wrote:
Sun Jun 07, 2020 8:41 pm
jocko6889 wrote:
Thu Jun 04, 2020 12:16 pm
RobSmith wrote:
Thu Jun 04, 2020 11:13 am


Hey, this is the first time I've seen anyone comment "lost methyl groups". Could someone explain what this means, please?
Byproducts from NAD+ use are excreted out the urine along with a methyl group. Depending on how much NMN you are using, this could cause a shortage of methyl groups, in which case you should supplement. Methyl groups are needed for synthesizing creatine for muscle and dopamine for the brain. Having a shortage could mean feeling tired and/or depressed.
Can this happen with SL NMN? Or just NAD+?
Either NMN or NAD+ can do it.
canadahealthy
Posts: 180
Joined: Tue Aug 20, 2019 5:31 pm

Re: NMN Dosage

Post by canadahealthy » Sat Jun 13, 2020 12:16 am

I would imagine one symptom of this could be fatigue, yes?

I feel more and more invigorated taking NMN and RSV. So if i was raising the dose level and began to feel fatigue, i would suspect i am maybe taking too much.

I would rather take less and NOT experience lost methyl groups than have to take more suppliments.
drkris69
Posts: 533
Joined: Tue Aug 20, 2019 2:41 pm

Re: NMN Dosage

Post by drkris69 » Wed Jun 24, 2020 1:34 pm

I recently added Methyl folate and Methyl B12 after reading the post from Jocko and I can honestly say I feel a difference in my mood and energy throughout the day. Definitely a nice compliment with taking NMN.
Drdavid
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Joined: Thu Aug 15, 2019 9:59 am

Re: NMN Dosage

Post by Drdavid » Mon Jun 29, 2020 9:24 am

Sci Rep. 2019; 9: 9772.
Published online 2019 Jul 5. doi: 10.1038/s41598-019-46120-z
PMCID: PMC6611812
PMID: 31278280
Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults
Dietrich Conze,#1 Charles Brenner,corresponding author2 and Claire L. Krugercorresponding author#1

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611812/
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