About NAD+ Restoration
Over the past few years there’s been a tremendous interest in boosting NAD+. In general, NAD+ decreases as we age, while boosting it supports several important healthspan processes and pro-longevity pathways.
The attention NAD+ has received is well-deserved. Cells rely on NAD+ to carry out hundreds of metabolic functions, including a vast array of processes ranging from energy creation to maintaining healthy DNA.
When your NAD+ levels are increased, your cells produce more energy, your good genes are “turned on”, DNA is repaired, and many other functions are optimized.
Current research also indicates that NAD deficiencies may trigger a host of metabolic and degenerative diseases – including obesity, Type II diabetes, chronic traumatic encephalopathy, Alzheimer’s, and Parkinson’s. When using NAD+,neurochemical imbalances can be restored to healthy.
NAD+ may actually prolong life, protect DNA, slow down aging and help restore function in neurodegenerative illness due to its effects on the genes that govern aging.
NAD has been shown to help the body produce ATP, protect and repair DNA, strengthen the immune system, lower cholesterol and blood pressure, and stimulate production of dopamine, serotonin, and noradrenaline, thereby improving mood.
Compelling research shows that NAD+ has a unique ability to protect tissues, induce DNA repair, and increase life span.
Bioavailability of oral NAD+ supplements is limited
Bioavailability is the study of how a supplement is digested in the GI tract and then absorbed and assimilated by the body. For the majority of nutrients, this process involves digestion and absorption through the small intestine.
NAD+ is the key end goal molecule that produces the beneficial biological effects desired in the body, but it has long been known that when taken as capsules NAD+ is broken down to Nicotinamide (NAM) in the GI tract.
In an effort to increase NAD+ the NAD+ precursors Nicotinamide Mono-Nucleotide (NMN) and Nicotinamide Riboside (NR) are also being used, but research from March 2018 showed that NMN and NR are also almost completely metabolized to NAM in the stomach and liver.
Sublingual delivery can bypass the GI tract
When supplied in a form that is not subject to digestion, such as our sublingual tablets, powder, liquid, or nasal spray, NAD+ can reach the bloodstream directly, without need to convert a precursor into the NAD+ your cells need.
Intravenous NAD+ is even more efficient.
Two different studies published in 2018 show NAD+ IV can be effective for increasing energy and controlling weight at just 1 mg/kg of bodyweight – approximately 100x less than typical dosages of NMN or NR that show similar results.
NAD+ Therapy involves a high dose intravenous infusion of NAD+ that goes straight into the bloodstream. IV therapy allows NAD+ to bypass the digestive system for better absorption.
Long Safety Record for NAD+ IV therapy
Studies done in the early 1960’s demonstrated the efficacy and safety of IV NAD in detoxifying patients from alcohol, opiates, tranquilizers and stimulants.
Researchers investigating brain health and longevity have found NAD+ is an essential coenzyme that promotes cellular regeneration. Studies have found replenishing cellular levels of NAD+ can repair DNA, protect brain cells from damage, reduce inflammation and turn on enzymes that help prevent aging.
Many chronic conditions, including chronic fatigue syndrome, neurodegenerative disease and mental health disorders have been linked to cellular dysfunction and dysregulation. NAD+ therapy may help reduce the symptoms of many chronic conditions, and may help individuals suffering from chronic conditions regain their vitality and strength.
- A pilot study done by Springfield Wellness Center, Springfield, LA, illustrates that NAD is an effective detox treatment for alcohol and opiate addicts and is effective in reducing and maintaining relapse episodes.
Intravenous Administration of Nicotinamide Adenine Dinucleotide Significantly Reduces Self Report Craving Ratings Associated with Opiate and Alcohol Withdrawal, Springfield Wellness Center, 2014
- As published in a 2014 paper, it is well known that NAD+ plays a key role in regulating metabolism and circadian rhythm through sirtuins, NAD+ becomes limiting during aging, affecting sirtuins’ activities, and supplementing key NAD+ intermediates can restore NAD+ levels and ameliorate age-associated pathophysiologies.
NAD+ and sirtuins in aging and disease, Trends in Cell Biology, 2014
- A new study (Gomes et al., 2013) shows that reduced levels of nicotinamide adenine dinucleotide (NAD+) contribute to the mitochondrial decay associated with skeletal muscle aging and that sirtuin 1 (SIRT1) modulates this process.
NAD+ Deficiency in Age-Related Mitochondrial Dysfunction, Cell Metabolism, 2014
- A study showed declining NAD(+) induces a a pseudohypoxic state that disrupts PGC-1α/β-independent nuclear-mitochondrial communication contributes to the decline in mitochondrial function with age, a process that is apparently reversible.
Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging, Cell. 2013 Dec