We have been the largest seller of NMN powder, capsules and tablets over the last year, but have continued exploring new delivery methods.
Now we want to tell you about what we think is the most convenient delivery method: LIQUID NAD+.
How we got here – Thanks to our customers
The first step was our PURE NMN POWDER. In late 2017, thanks to tips from customers, we realized that opening capsules of our NMN and putting the powder under the tongue (sublingual) provided a very noticeable increase in energy and endurance, as it delivers the NMN directly to the bloodstream.
Around the same time, studies were being published that show oral supplements of NR and NMN are almost completely digested in the stomach and liver.
So we rolled out our PURE NMN powder and told our customers.
After a few months we found that 100% of the feedback was positive and confirmed this was a far more effective delivery method.
NO MORE CAPSULES
By March 2018, we were no longer comfortable selling the capsules that we knew were so inferior to the powder.
So, even though we were easily the biggest seller of NMN capsules on Amazon, and sold even more on our own website, we STOPPED SELLING CAPSULES. It cost us a lot of lost sales, but we believe it was the right thing to do.
Increased NAD+ is the goal
Increased levels of NAD+ is the goal with NR and NMN supplementation. Research such as this study by Elysium Health measure the increase of NAD+ levels in the blood as a primary measure of the effectiveness.
Bioavailability of NAD+ capsules even worse than NR and NMN
Doctors know that NAD+ has some very positive benefits when used intravenously in NAD+ clinics. However, NAD+ is twice as large a molecule, so is degraded even more than NR and NMN when taken as a capsule.
Sublingual delivery solves the problem
Like NMN, NAD+ is very hygroscopic, which is required for absorption in the oral mucosa. When we found how much more effective NMN is when delivered sublingually to bypass the GI tract, we quickly realized that the same delivery method might work for NAD+. The only question was, would it be absorbed as readily.
Bingo! It only took about 1 minute after receiving a sample of NAD+ powder before we had our answer. Take a scoop of 250 Mg of NAD+ under the tongue and most people can feel an immediate stimulus – much quicker and stronger than with NMN.
That doesn’t mean NAD+ provides all the benefits that NMN does, but it is quickly absorbed and has a more immediate impact. For more about what we believe are the benefits of sublingual NAD+ vs NMN.
It has been a struggle to get the formula just right. Taste, durability, stability, dissolve time, safe and natural ingredients, and size all add complexity.
Now, we are now very happy with our NMNs™ and Bio-NAD+ Sublingual tablets
Why bother with a Liquid NMN or NAD+?
We have also been looking for a better solution for some customers who still had difficulty with the powder and tablets delivery methods, including:
- Seniors that have trouble taking tablets or powder sublingually
- Those that want pure NMN with on the go convenience
The challenge of using a Liquid NMN
NMN is amazingly hygroscopic and large quantities of our powder dissolve instantly in water.
Nearly all research with mice is done by providing NMN in the drinking water.
The problem is that although NMN is stable in a powder form, it degrades in water in a matter of weeks, so it would be very difficult for us to bottle and deliver to customers while ensuring it does not lose potency.
Researchers have found NMN maintains its purity for a few weeks, so they typically mix NMN in water once a week, and test throughout the week to ensure it does not degrade and interfere with their results.
What about NAD+
NR is very unstable, and degrades in minutes when mixed in water (or in the bloodstream).
NMN is stable in the blood, and in water for a few weeks before it degrades. Researchers typically use a batch for about a week.
Our research partner has found no significant degradation of the formula we use in our Liquid NAD+ after 18 months. We list a shelf life of 12 months at room temperature, but you can refrigerate if you plan on storing it for many months.
What we thought would be an inconvenience, is really the exact opposite!
Carrying a bottle around throughout the day is even easier than carrying a tin of sublingual tablets.
I previously preferred the powder throughout the day, and took tablets at the gym or when I didn’t have a jar of powder handy.
But now, I don’t feel inclined to take either and am very happy carrying a little squeeze bottle with me throughout the day.
It may be slightly less effective if you swallow the liquid. Any that is not absorbed in the mouth could potentially end up in the GI tract and suffer the same fate as capsules. But we believe that the minute quantity of liquid is mostly absorbed in the esophagus, so very little, if any, get digested in the stomach as capsules do.
DIY Liquid NMN
We do have thousands of customers who love our NMN powder, so we decided to go back to an earlier idea and explore a DIY liquid NMN.
We had rejected this idea back in March because we thought it would be a tiny fraction of users that would want to bother with this approach. But feedback from users tell us many would like a liquid NMN product. So until we can produce a formula that is stable for many months, we are sharing the info below on making your own NMN liquid.
Squirt or drops?
Using a squirt bottle is even simpler than opening a bottle and swallowing a capsule. But it is a little more difficult to just the exact quantity you are getting.
With an eyedropper type bottle you can get fairly accurate 125 mg per squirt but is slightly less convenient than a squirt bottle. We show some examples of both types of bottles we like below.
One difference between NMN and NAD+ is in dosage. NAD+ is more stimulative than NMN – and also lasts longer in the bloodstream – so we recommend less frequent dosages and lower quantities per day.
We have tested up to 5 grams per day of each, but anything over 2 grams is very stimulative and makes it difficult to sleep. So our recommendations are:
Do not exceed 1,500 Mg per day total of NMN.
Do not exceed 1,000 Mg per day total of NAD+
How to mix
Its pretty simple, but heres the basics:
15 ml of water will dissolve 3 grams of NMN, so if you want to mix a 15 ml bottle:
Fill your bottle with water, then dump it in a small cup to mix. Add 3s gram of NMN powder for each 15 ml of water.
1 full teaspoon of NMN powder is approximately 3 grams.
Stir a bit – it should dissolve completely in a few seconds.
Pour it back into the bottle.Thats it!
If you have 5 bottles to fill, you can also mix a full 12 gram jar of powder. Pour 4 bottles of water into the mixing cup and dump the full jar of powder. Pour contents back into the 5 bottles.
How to use
We recommend similar dosages for a liquid NMN as we do with the tablets – 4-8 times a day with about 125 mg per dose.
125 Mg per squirt
A full squirt from the squeeze bulb will empty a 15 ml bottle in about 20 squirts. So if you mixed 3 grams of powder in the 15 ml bottle, each squirt will deliver around 125-150 Mg of NMN