AS WE AGE, INFLAMMATION BECOMES THE KEY CONSUMER OF NAD+ AND LEVELS DROP (54,67).
Decreasing systemic inflammation is likely the most effective thing you can do to minimize NAD+ consumption so it is available for other purposes.
Did you know that fat cells secrete cytokines that increase systemic inflammation, disease and aging? (73,74,75).
- MSM – Methylsulfonylmethane – 150 mg
- Micronized Curcumin – 150 mg
- Boswellia Serrata – 125 mg
- Berberine 115 mg
- Silibinin (from Milk Thistle) – 100 mg
- Piperine – 10 mg
health-specific outcome measures are improved with MSM supplementation, including inflammation, joint/muscle pain, oxidative stress, and antioxidant capacity
Pre-treatment with MSM, prior to exhaustive exercise, prevented the over-stress of immune cells 
As a therapeutic agent, MSM utilizes its unique penetrability properties to alter physiological effects at the cellular and tissue levels. Furthermore, MSM has the ability to act as a carrier or co-transporter for other therapeutic agents, even furthering its potential application
MSM was also shown to be effective in reducing arthritis pain when used in combination with boswellic acid 
MSM is effective at reducing other inflammatory pathologies in humans as well…
SILIBININ (AKA SILYBIN, SILIMARIN, OR MILK THISTLE)
Silibinin, the main component of silymarin, has been proposed as a nutraceutical for the treatment of NAFLD. In this study, we aimed to identify whether silibinin may influence the NAD⁺/SIRT1 axis. To this end, C57BL/6 mice were fed a high fat diet (HFD) for 16 weeks, and were treated with silibinin or vehicle during the last 8 weeks. HepG2 cells were treated with 0.25 mM palmitate for 24 h with silibinin 25 µM or vehicle. HFD and palmitate administration led to oxidative stress, poly-(ADP-ribose)-polymerase (PARP) activation, NAD⁺ consumption, and lower SIRT1 activity. In mice fed the HFD, and in HepG2 treated with palmitate, we consistently observed lower levels of phospho-AMPKThr172 and phospho-acetyl-CoA carboxylaseSer79 and higher levels of nuclear sterol regulatory element-binding protein 1 activity, indicating de novo lipogenesis. Treatment of mice and HepG2 with silibinin abolished oxidative stress, and inhibited PARP activation thus restoring the NAD⁺ pool. In agreement with preserved NAD⁺ levels, SIRT1 activity and AMPK phosphorylation returned to control levels in mice and HepG2. Our results further indicate silibinin as a promising molecule for the treatment of NAFLD.
Bioavailability Issues & Ways to Overcome Them
Silybin, the main active component in the standardized milk thistle extract Silymarin, has poor bioavailability. Only around 20–50% of it gets absorbed from the gut. This is because silybin can’t dissolve in water that makes most of the stomach and gut fluids. What’s even worse is that stomach acid can also degrade it, so sometimes it won’t even reach the gut.
There are many ways to overcome its bioavailability issues.
- Berberine increases the bioavailability of silybin and the two act together in synergy [R]
- Other flavonoids increase its absorption [R]
This product is not intended to diagnose, treat, cure, or prevent any disease.