WHAT IS NAD+ ?
Scientists have now confirmed a direct link between falling NAD+ levels and aging in both animal and in human subjects.
NAD+ DECLINES WITH AGE
Poor Bioavailability from Capsules
NAD+ not effective in drinking water or in capsule form
The NAD+ molecule is twice as large as NR or NMN, and is totally degraded in the Gastro-Intestinal tract, so researchers do not use NAD+ in drinking water of mice and it is not sold in capsule form for humans.
NAD+ in IV or IP injections
Research has been successful using NAD+ injections in mice.
In humans, clinics that provide NAD+ by IV are exploding in popularity, even though they charge over $1,000 a day and require the patient to be hooked up to a drip IV for 8 hours.
NMN and NR poor bioavailability in capsules
NMN and NR capsules are only partially digested in the stomach, but are almost totally metabolized in the liver and excreted as NAM (Liu, 2018).
Sublingual delivery solves the bioavailability problem
Molecules like NMN, NR and NAD+ that have low molecular weight and are hydrophilic can be absorbed through the capillaries under the tongue directly into the bloodstream. This is called Sublingual (under the tongue) delivery.
This solves the bioavailability problem of capsules that get digested in the stomach, so NAD+ can be used instead of NAD+ precursors. It also greatly improves the effectiveness of NMN.
OTHER WAYS TO INCREASE NAD+
There are a number of lifestyle changes you can make to increase NAD+ in you body.
It’s well known that Calorie Restriction (CR) can extend longevity by 30–50% in many mammals (32)
CR has also been shown to increase NAD+ levels in the body , thru these pathways:
- Lowering blood glucose levels minimizes inflammation, which consumes NAD+.
- The ketone body BHB signals to increase AMPK to produce more NAD+
- Burning Ketones for fuel instead of glucose requires 1/2 as much NAD+
KETOSIS BOOSTS NAD+
Ketosis is a metabolic state in which fat provides most of the fuel for the body. It occurs when there is limited access to glucose (blood sugar), which is the preferred fuel source for many cells in the body.
Intermittent or Periodic Ketosis is also effective at extending lifespan and likely achieves much of the benefit (36,37).
Some research even shows more benefit from a cyclical rather than a full time Ketogenic Diet (71).
The Red bars in the chart at left show the increased levels of the Ketone Body BHB produced from a cyclical Keto diet, resulting in Increased NAD+ and greatly improved neurological function and health.
EXERCISE THAT BOOSTS NAD+
Researchers are finding that 2-3 short bouts of High Intensity Interval Training (HIIT) per week is far more effective at lowering inflammation (and increasing NAD+), especially among older adults (55)
Exercise is very effective at boosting AMPK and NAD+, especially when performed at times of low blood glucose levels ( more about HIIT ).
Short bouts of HIIT accomplishes the goal, while avoiding overtraining from endurance workouts which increases inflammation and consumes NAD+ (55).